Ricardo Tapia Selected Research

alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)

1/2017	Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism.
1/2017	Chronic GABAergic blockade in the spinal cord in vivo induces motor alterations and neurodegeneration.
1/2016	Motor Alterations Induced by Chronic 4-Aminopyridine Infusion in the Spinal Cord In vivo: Role of Glutamate and GABA Receptors.
1/2016	Mitochondrial Dysfunction during the Early Stages of Excitotoxic Spinal Motor Neuron Degeneration in Vivo.
1/2016	Neuropathological characterization of spinal motor neuron degeneration processes induced by acute and chronic excitotoxic stimulus in vivo.
5/2015	Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
3/2014	Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo.
3/2012	Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo.
12/2010	VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.
3/2009	Chronic elevation of extracellular glutamate due to transport blockade is innocuous for spinal motoneurons in vivo.

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Ricardo Tapia Research Topics

Disease

14	Paralysis (Palsy) 01/2017 - 05/2004
9	Seizures (Absence Seizure) 01/2016 - 09/2002
9	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2016 - 05/2004
5	Epilepsy (Aura) 10/2015 - 09/2002
3	Gliosis 01/2017 - 03/2009
1	Chronic Disease (Chronic Diseases) 01/2016
1	Necrosis 01/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2016
1	Rupture 01/2016
1	Status Epilepticus (Complex Partial Status Epilepticus) 07/2014
1	Ischemia 12/2008
1	Spasm (Spasms) 05/2004

Drug/Important Bio-Agent (IBA)

14	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2017 - 05/2004
14	Glutamic Acid (Glutamate)FDA Link 01/2016 - 09/2002
6	4-Aminopyridine (4 Aminopyridine)FDA Link 01/2016 - 10/2003
6	N-Methylaspartate (NMDA)IBA 10/2015 - 09/2002
6	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2014 - 09/2002
5	Pyruvic Acid (Pyruvate)IBA 01/2016 - 04/2007
4	PropionatesIBA 01/2016 - 05/2004
4	AMPA Receptors (AMPA Receptor)IBA 01/2016 - 05/2004
4	Dizocilpine Maleate (Dizocilpine)IBA 10/2015 - 10/2003
3	Glutamate Receptors (Glutamate Receptor)IBA 05/2015 - 09/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2012 - 10/2007
2	Glial Fibrillary Acidic ProteinIBA 05/2015 - 03/2009
2	maleic acid (maleate)IBA 12/2005 - 09/2002
2	IminesIBA 12/2005 - 09/2002
2	Okadaic AcidIBA 10/2003 - 09/2002
2	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 10/2003 - 09/2002
2	Serine (L-Serine)FDA Link 10/2003 - 09/2002
1	BicucullineIBA 01/2017
1	QuercetinIBA 01/2017
1	ResveratrolIBA 01/2017
1	Sirtuin 1IBA 01/2017
1	CaspasesIBA 01/2016
1	Caspase 3 (Caspase-3)IBA 01/2016
1	Ionotropic Glutamate ReceptorsIBA 01/2016
1	gamma-Aminobutyric Acid (GABA)IBA 10/2015
1	Protein Isoforms (Isoforms)IBA 10/2015
1	pyridoxal phosphate gamma-glutamyl hydrazoneIBA 10/2015
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 10/2015
1	HydrazonesIBA 10/2015
1	Excitatory Amino Acid AntagonistsIBA 10/2015
1	trans-sodium crocetinate (crocetin)IBA 10/2015
1	thiosemicarbazideIBA 10/2015
1	acetoacetic acid (acetoacetate)IBA 07/2014
1	S-ethyl glutathioneIBA 07/2014
1	Lactic Acid (Lactate)FDA LinkGeneric 03/2014
1	CreatineIBA 03/2014
1	Pregnanolone (Allopregnanolone)IBA 03/2012
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2010
1	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 03/2009
1	propionic acid (potassium propionate)IBA 08/2008
1	cresyl violetIBA 08/2008
1	leupeptinIBA 08/2008
1	Superoxide Dismutase-1IBA 11/2007
1	CationsIBA 04/2007
1	EstersIBA 04/2007
1	Chelating AgentsIBA 04/2007
1	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl esterIBA 04/2007
1	1-naphthylacetylspermineIBA 04/2007
1	1,2- bis(2- aminophenoxy)ethane- N,N,N',N'- tetraacetic acid (BAPTA)IBA 04/2007
1	AcidsIBA 10/2003
1	Halothane (Fluothane)FDA Link 10/2003
1	Cytoskeletal ProteinsIBA 10/2003
1	Threonine (L-Threonine)FDA Link 10/2003
1	Protein Kinases (Protein Kinase)IBA 09/2002
1	Proteins (Proteins, Gene)FDA Link 09/2002
1	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)IBA 09/2002